Recent Publications

For a more updated and full publication list see Bibliography

Highlighted Publications

Loss of function in the neurodevelopmental disease and schizophrenia-associated gene CYFIP1 in human microglia-like cells supports a functional role in synaptic engulfment

Recent Papers

Psychiatric Symptoms, Treatment Uptake, and Barriers to Mental Health Care Among US Adults With Post-COVID-19 Condition
April 25, 2024
CONCLUSIONS AND RELEVANCE: The findings of this study suggest that people with PCC have a higher prevalence of psychiatric symptoms than other adults but are more likely to experience cost-related barriers to accessing therapy. Care […]
Identifying data-driven subtypes of major depressive disorder with electronic health records
April 2, 2024
CONCLUSION: These data-driven subtypes, drawing on representative clinical cohorts, merit further investigation for their utility in identifying more homogeneous patient populations for basic as well as clinical investigation.
Clinical decision support for bipolar depression using large language models
March 14, 2024
Management of depressive episodes in bipolar disorder remains challenging for clinicians despite the availability of treatment guidelines. In other contexts, large language models have yielded promising results for supporting clinical decisionmaking. We developed 50 sets […]
Tissue- and cell-type-specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models
March 8, 2024
No abstract

Selected Publications List

Rapino F, Natoli T, Limone F, O’Connor E, Blank J, Tegtmeyer M, Chen W, Norabuena E, Narula J, Hazelbaker D, Angelini G, Barrett L, O’Neil A, Beattie UK, Thanos JM, de Rivera H, Sheridan SD, Perlis RH, McCarroll SA, Stevens B, Subramanian A, Nehme R, Rubin LL. Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes. Stem Cell Reports. 2023 01 10; 18(1):237-253. PMID: 36563689; PMCID: PMC9860128.

Samudyata, Oliveira AO, Malwade S, de Sousa NR, Goparaju SK, Gracias J, Orhan F, Steponaviciute L, Schalling M, Sheridan SD, Perlis RH, Rothfuchs AG, Sellgren CM. SARS-CoV-2 promotes microglial synapse elimination in human brain organoids. Mol Psychiatry. 2022. https://doi.org/10.1038/s41380-022-01786-2

Shook LL, Sullivan EL, Lo JO, Perlis RH, Edlow AG. COVID-19 in pregnancy: implications for fetal brain development. Trends Mol Med. 2022 Apr;28(4):319-330. doi: 10.1016/j.molmed.2022.02.004. Epub 2022 Feb 14. Review. PubMed PMID: 35277325; PubMed Central PMCID: PMC8841149.

Sheridan SD, Horng JE, Perlis RH. Patient-Derived In Vitro Models of Microglial Function and Synaptic Engulfment in Schizophrenia. Biol Psychiatry. 2022 Jan 19;. doi: 10.1016/j.biopsych.2022.01.004. [Epub ahead of print] Review. PubMed PMID: 35232567.

Perlis RH, Ognyanova K, Santillana M, Lin J, Druckman J, Lazer D, Green J, Simonson M, Baum MA, Della Volpe J. Association of Major Depressive Symptoms With Endorsement of COVID-19 Vaccine Misinformation Among US Adults. JAMA Netw Open. 2022 Jan 4;5(1):e2145697. doi: 10.1001/jamanetworkopen.2021.45697. PubMed PMID: 35061036; PubMed Central PMCID: PMC8783266.

Perlis RH, Green J, Simonson M, Ognyanova K, Santillana M, Lin J, Quintana A, Chwe H, Druckman J, Lazer D, Baum MA, Della Volpe J. Association Between Social Media Use and Self-reported Symptoms of Depression in US Adults. JAMA Netw Open. 2021 Nov 1;4(11):e2136113. doi: 10.1001/jamanetworkopen.2021.36113. PubMed PMID: 34812844; PubMed Central PMCID: PMC8611479.

Perlis RH, Ognyanova K, Quintana A, Green J, Santillana M, Lin J, Druckman J, Lazer D, Simonson MD, Baum MA, Chwe H. Gender-specificity of resilience in major depressive disorder. Depress Anxiety. 2021 Oct;38(10):1026-1033. doi: 10.1002/da.23203. Epub 2021 Aug 9. PubMed PMID: 34370885.

Yu JZ, Wang J, Sheridan SD, Perlis RH, Rasenick MM. N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cells. Mol Psychiatry. 2021 Sep;26(9):4605-4615. doi: 10.1038/s41380-020-0786-5. Epub 2020 Jun 5. PubMed PMID: 32504049.

Castro VM, McCoy TH, Perlis RH. Assessment of the Performance Consistency of an Adverse Outcome Prediction Tool for Patients Hospitalized With COVID-19. JAMA Netw Open. 2021 Jul 1;4(7):e2118413. doi: 10.1001/jamanetworkopen.2021.18413. PubMed PMID: 34313745; PubMed Central PMCID: PMC8317002.

McCoy TH Jr, Castro VM, Hart KL, Perlis RH. Stratified delirium risk using prescription medication data in a state-wide cohort. Gen Hosp Psychiatry. 2021 Jul-Aug;71:114-120. doi: 10.1016/j.genhosppsych.2021.05.001. Epub 2021 May 7. PubMed PMID: 34091195; PubMed Central PMCID: PMC8249339.

Perlis RH, Santillana M, Ognyanova K, Green J, Druckman J, Lazer D, Baum MA. Factors Associated With Self-reported Symptoms of Depression Among Adults With and Without a Previous COVID-19 Diagnosis. JAMA Netw Open. 2021 Jun 1;4(6):e2116612. doi: 10.1001/jamanetworkopen.2021.16612. PubMed PMID: 34115130; PubMed Central PMCID: PMC8196339.

Castro VM, Gunning FM, McCoy TH, Perlis RH. Mood Disorders and Outcomes of COVID-19 Hospitalizations. Am J Psychiatry. 2021 Jun;178(6):541-547. doi: 10.1176/appi.ajp.2020.20060842. Epub 2021 Apr 6. PubMed PMID: 33820425.

Tilak M, Alural B, Wismer SE, Brasher MI, New LA, Sheridan SD, Perlis RH, Coppolino MG, Lalonde J, Jones N. Adaptor Protein ShcD/SHC4 Interacts with Tie2 Receptor to Synergistically Promote Glioma Cell Invasion. Mol Cancer Res. 2021 May;19(5):757-770. doi: 10.1158/1541-7786.MCR-20-0188. Epub 2021 Jan 25. PubMed PMID: 33495401.

Sheridan SD, Thanos JM, De Guzman RM, McCrea LT, Horng JE, Fu T, Sellgren CM, Perlis RH, Edlow AG. Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure. Transl Psychiatry. 2021 Mar 19;11(1):179. doi: 10.1038/s41398-021-01287-w. PubMed PMID: 33741894; PubMed Central PMCID: PMC7976669.

Perlis RH, Ognyanova K, Santillana M, Baum MA, Lazer D, Druckman J, Della Volpe J. Association of Acute Symptoms of COVID-19 and Symptoms of Depression in Adults. JAMA Netw Open. 2021 Mar 1;4(3):e213223. doi: 10.1001/jamanetworkopen.2021.3223. PubMed PMID: 33710287; PubMed Central PMCID: PMC7955267.

Clapp MA, McCoy TH, James KE, Kaimal AJ, Perlis RH. The utility of electronic health record data for identifying postpartum hemorrhage. Am J Obstet Gynecol MFM. 2021 Mar;3(2):100305. doi: 10.1016/j.ajogmf.2020.100305. Epub 2021 Jan 6. PubMed PMID: 33421646.

Boag W, Kovaleva O, McCoy TH Jr, Rumshisky A, Szolovits P, Perlis RH. Hard for humans, hard for machines: predicting readmission after psychiatric hospitalization using narrative notes. Transl Psychiatry. 2021 Jan 11;11(1):32. doi: 10.1038/s41398-020-01104-w. PubMed PMID: 33431794; PubMed Central PMCID: PMC7801508.

Hart KL, Perlis RH. Authorship inequality: a bibliometric study of the concentration of authorship among a diminishing number of individuals in high-impact medical journals, 2008-2019. BMJ Open. 2021 Jan 6;11(1):e046002. doi: 10.1136/bmjopen-2020-046002. PubMed PMID: 33408219; PubMed Central PMCID: PMC7789455.

Perlis RH, Haneuse SJPA, Rubenfeld GD, Fihn SD, Rivara FP. Reporting Clinical Studies Affected by the COVID-19 Pandemic: Guidelines for Authors. JAMA Netw Open. 2021 Jan 4;4(1):e2036155. doi: 10.1001/jamanetworkopen.2020.36155. PubMed PMID: 33443576.

Pradier MF, Hughes MC, McCoy TH Jr, Barroilhet SA, Doshi-Velez F, Perlis RH. Predicting change in diagnosis from major depression to bipolar disorder after antidepressant initiation. Neuropsychopharmacology. 2021 Jan;46(2):455-461. doi: 10.1038/s41386-020-00838-x. Epub 2020 Sep 14. PubMed PMID: 32927464; PubMed Central PMCID: PMC7852537.

Haggarty SJ, Karmacharya R, Perlis RH. Advances toward precision medicine for bipolar disorder: mechanisms & molecules. Mol Psychiatry. 2021 Jan;26(1):168-185. doi: 10.1038/s41380-020-0831-4. Epub 2020 Jul 7. Review. PubMed PMID: 32636474.

McDermott MBA, Wang J, Zhao WN, Sheridan SD, Szolovits P, Kohane I, Haggarty SJ, Perlis RH. Deep Learning Benchmarks on L1000 Gene Expression Data. IEEE/ACM Trans Comput Biol Bioinform. 2020 Nov-Dec;17(6):1846-1857. doi: 10.1109/TCBB.2019.2910061. Epub 2020 Dec 8. PubMed PMID: 30990190; PubMed Central PMCID: PMC6980363.

Perlis RH. Essential Work: Psychiatric Clinical Investigation in the Midst of a Pandemic. Am J Psychiatry. 2020 Dec 1;177(12):1117-1118. doi: 10.1176/appi.ajp.2020.20050722. PubMed PMID: 33256455.

Castro VM, McCoy TH, Perlis RH. Laboratory Findings Associated With Severe Illness and Mortality Among Hospitalized Individuals With Coronavirus Disease 2019 in Eastern Massachusetts. JAMA Netw Open. 2020 Oct 1;3(10):e2023934. doi: 10.1001/jamanetworkopen.2020.23934. PubMed PMID: 33125498; PubMed Central PMCID: PMC7599467.

Perlis RH, Fihn SD. Hard Truths About Suicide Prevention. JAMA Netw Open. 2020 Oct 1;3(10):e2022713. doi: 10.1001/jamanetworkopen.2020.22713. PubMed PMID: 33084895.

Perlis RH, Dowd D, Fava M, Lencz T, Krause DS. Randomized, controlled, participant- and rater-blind trial of pharmacogenomic test-guided treatment versus treatment as usual for major depressive disorder. Depress Anxiety. 2020 Sep;37(9):834-841. doi: 10.1002/da.23029. Epub 2020 May 7. PubMed PMID: 32383277.

McCoy TH Jr, Pellegrini AM, Perlis RH. Differences among Research Domain Criteria score trajectories by Diagnostic and Statistical Manual categorical diagnosis during inpatient hospitalization. PLoS One. 2020;15(8):e0237698. doi: 10.1371/journal.pone.0237698. eCollection 2020. PubMed PMID: 32842139; PubMed Central PMCID: PMC7447552.

Kathuria A, Lopez-Lengowski K, Jagtap SS, McPhie D, Perlis RH, Cohen BM, Karmacharya R. Transcriptomic Landscape and Functional Characterization of Induced Pluripotent Stem Cell-Derived Cerebral Organoids in Schizophrenia. JAMA Psychiatry. 2020 Jul 1;77(7):745-754. doi: 10.1001/jamapsychiatry.2020.0196. PubMed PMID: 32186681; PubMed Central PMCID: PMC7081156.

Jagtap S, Thanos JM, Fu T, Wang J, Lalonde J, Dial TO, Feiglin A, Chen J, Kohane I, Lee JT, Sheridan SD, Perlis RH. Aberrant mitochondrial function in patient-derived neural cells from CDKL5 deficiency disorder and Rett syndrome. Hum Mol Genet. 2019 Nov 1;28(21):3625-3636. doi: 10.1093/hmg/ddz208. PubMed PMID: 31518399; PubMed Central PMCID: PMC6927463.

Zhao WN, Hylton NK, Wang J, Chindavong PS, Alural B, Kurtser I, Subramanian A, Mazitschek R, Perlis RH, Haggarty SJ. Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA). Mol Cell Neurosci. 2019 Sep;99:103386. doi: 10.1016/j.mcn.2019.06.006. Epub 2019 Jun 14. PubMed PMID: 31202891; PubMed Central PMCID: PMC7001743.

Sellgren CM, Gracias J, Watmuff B, Biag JD, Thanos JM, Whittredge PB, Fu T, Worringer K, Brown HE, Wang J, Kaykas A, Karmacharya R, Goold CP, Sheridan SD, Perlis RH. Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning. Nat Neurosci. 2019 Mar;22(3):374-385. doi: 10.1038/s41593-018-0334-7. Epub 2019 Feb 4. PubMed PMID: 30718903; PubMed Central PMCID: PMC6410571.

Sellgren CM, Gracias J, Jungholm O, Perlis RH, Engberg G, Schwieler L, Landen M, Erhardt S. Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls. Transl Psychiatry. 2019 Jan 29;9(1):37. doi: 10.1038/s41398-019-0378-9. PubMed PMID: 30696814; PubMed Central PMCID: PMC6351610.

McCoy TH, Castro VM, Snapper LA, Hart KL, Perlis RH. Efficient genome-wide association in biobanks using topic modeling identifies multiple novel disease loci. Mol Med. 2017 Nov;23:285-294. doi: 10.2119/molmed.2017.00100. Epub 2017 Aug 31. PubMed PMID: 28861588; PubMed Central PMCID: PMC5681697.